2xhl
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xhl' size='340' side='right'caption='[[2xhl]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='2xhl' size='340' side='right'caption='[[2xhl]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xhl]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xhl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHL FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s0d|1s0d]], [[1epw|1epw]], [[1g9b|1g9b]], [[1f82|1f82]], [[2etf|2etf]], [[1i1e|1i1e]], [[1s0f|1s0f]], [[1g9a|1g9a]], [[1g9c|1g9c]], [[1s0b|1s0b]], [[1s0g|1s0g]], [[1s0c|1s0c]], [[1g9d|1g9d]], [[1z0h|1z0h]], [[1f31|1f31]], [[1s0e|1s0e]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s0d|1s0d]], [[1epw|1epw]], [[1g9b|1g9b]], [[1f82|1f82]], [[2etf|2etf]], [[1i1e|1i1e]], [[1s0f|1s0f]], [[1g9a|1g9a]], [[1g9c|1g9c]], [[1s0b|1s0b]], [[1s0g|1s0g]], [[1s0c|1s0c]], [[1g9d|1g9d]], [[1z0h|1z0h]], [[1f31|1f31]], [[1s0e|1s0e]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhl OCA], [https://pdbe.org/2xhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhl RCSB], [https://www.ebi.ac.uk/pdbsum/2xhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhl ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 10:53, 13 April 2022
Structure of a functional derivative of Clostridium botulinum neurotoxin type B
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