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3i3r

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==X-ray structure dihydrofolate reductase/thymidylate synthase from babesia bovis at 2.35A resolution==
==X-ray structure dihydrofolate reductase/thymidylate synthase from babesia bovis at 2.35A resolution==
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<StructureSection load='3i3r' size='340' side='right' caption='[[3i3r]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='3i3r' size='340' side='right'caption='[[3i3r]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3i3r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Babesia_bovis_t2bo Babesia bovis t2bo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I3R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3i3r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Babesia_bovis_t2bo Babesia bovis t2bo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I3R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BBOV_II000780 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484906 Babesia bovis T2Bo])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BBOV_II000780 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484906 Babesia bovis T2Bo])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3r OCA], [http://pdbe.org/3i3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i3r RCSB], [http://www.ebi.ac.uk/pdbsum/3i3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3r OCA], [https://pdbe.org/3i3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i3r RCSB], [https://www.ebi.ac.uk/pdbsum/3i3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A7ASX7_BABBO A7ASX7_BABBO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
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[[https://www.uniprot.org/uniprot/A7ASX7_BABBO A7ASX7_BABBO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3i3r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3i3r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Babesia bovis t2bo]]
[[Category: Babesia bovis t2bo]]
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[[Category: Large Structures]]
[[Category: Thymidylate synthase]]
[[Category: Thymidylate synthase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]

Revision as of 10:57, 13 April 2022

X-ray structure dihydrofolate reductase/thymidylate synthase from babesia bovis at 2.35A resolution

PDB ID 3i3r

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