1gwc

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[[Image:1gwc.gif|left|200px]]
[[Image:1gwc.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1gwc |SIZE=350|CAPTION= <scene name='initialview01'>1gwc</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1gwc", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+C'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1gwc| PDB=1gwc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwc OCA], [http://www.ebi.ac.uk/pdbsum/1gwc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gwc RCSB]</span>
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}}
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'''THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION'''
'''THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION'''
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[[Category: Lapthorn, A J.]]
[[Category: Lapthorn, A J.]]
[[Category: Thom, R.]]
[[Category: Thom, R.]]
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[[Category: glutathione s-transferase]]
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[[Category: Glutathione s-transferase]]
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[[Category: herbicide detoxification]]
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[[Category: Herbicide detoxification]]
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[[Category: plant]]
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[[Category: Plant]]
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[[Category: tau class]]
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[[Category: Tau class]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:05:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:39 2008''
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Revision as of 15:05, 2 May 2008

Image:1gwc.gif

Template:STRUCTURE 1gwc

THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION


Overview

Glutathione S-transferases (GSTs) from the phi (GSTF) and tau (GSTU) classes are unique to plants and play important roles in stress tolerance and secondary metabolism as well as catalyzing the detoxification of herbicides in crops and weeds. We have cloned and functionally characterized a group of GSTUs from wheat treated with fenchlorazole-ethyl, a herbicide safener. One of these enzymes, TaGSTU4-4, was highly active in conjugating the chemically distinct wheat herbicides fenoxaprop and dimethenamid. The structure of TaGSTU4-4 has been determined at 2.2 A resolution in complex with S-hexylglutathione. This enzyme is the first tau class GST structure to be determined and most closely resembles the omega class GSTs, but without the unique N-terminal extension or active site cysteine. The X-ray structure identifies key amino acid residues in the hydrophobic binding site and provides insights into the substrate specificity of these enzymes.

About this Structure

1GWC is a Single protein structure of sequence from Aegilops tauschii. Full crystallographic information is available from OCA.

Reference

Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification., Thom R, Cummins I, Dixon DP, Edwards R, Cole DJ, Lapthorn AJ, Biochemistry. 2002 Jun 4;41(22):7008-20. PMID:12033934 Page seeded by OCA on Fri May 2 18:05:38 2008

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