Terminase
From Proteopedia
(Difference between revisions)
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The large subunit of Ter is composed of an <scene name='77/775254/Cv/5'>N-terminal ATPase domain, a linker region and a C-terminal nuclease domain</scene>. ATP binds to the protein in a <scene name='77/775254/Cv/6'>groove between the ATPase domain and the linker region</scene><ref>PMID:23630261</ref>. | The large subunit of Ter is composed of an <scene name='77/775254/Cv/5'>N-terminal ATPase domain, a linker region and a C-terminal nuclease domain</scene>. ATP binds to the protein in a <scene name='77/775254/Cv/6'>groove between the ATPase domain and the linker region</scene><ref>PMID:23630261</ref>. | ||
| + | == 3D Structures of terminase == | ||
| + | [[Terminase 3D Structures ]] | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of terminase == | == 3D Structures of terminase == | ||
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**[[3n4p]], [[3n4q]] – HvTer nuclease domain – Herpesvirus<br /> | **[[3n4p]], [[3n4q]] – HvTer nuclease domain – Herpesvirus<br /> | ||
**[[6ey7]] – HvTer nuclease domain + inhibitor<br /> | **[[6ey7]] – HvTer nuclease domain + inhibitor<br /> | ||
| - | **[[3hef]] – Ter – Bacteriophage T7 <br /> | + | **[[3hef]], [[7lxs]] – Ter – Bacteriophage T7 <br /> |
**[[4zc3]], [[2cmp]] – Sf6Ter nuclease domain – Bacteriophage Sf6 <br /> | **[[4zc3]], [[2cmp]] – Sf6Ter nuclease domain – Bacteriophage Sf6 <br /> | ||
**[[4dyc]], [[4dzj]], [[4dzp]] – Sf6Ter nuclease domain (mutant) <br /> | **[[4dyc]], [[4dzj]], [[4dzp]] – Sf6Ter nuclease domain (mutant) <br /> | ||
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**[[3p9a]] – Ter – Bacteriophage P22 <br /> | **[[3p9a]] – Ter – Bacteriophage P22 <br /> | ||
**[[6v1i]] – Ter – Thermus virus – Cryo EM<br /> | **[[6v1i]] – Ter – Thermus virus – Cryo EM<br /> | ||
| - | **[[6ejq]] – | + | **[[6ejq]] – TpTer – Thermus phage<br /> |
| - | **[[ | + | **[[7lw0]] – Ter – ''E. coli'' virus λ <br /> |
| + | **[[6hn7]] – Ter + RPPC <br /> | ||
**[[7joq]] – Ter – Pseudomonas phage NV1<br /> | **[[7joq]] – Ter – Pseudomonas phage NV1<br /> | ||
**[[6w7t]] – Ter – Pseudomonas phage PaP3<br /> | **[[6w7t]] – Ter – Pseudomonas phage PaP3<br /> | ||
| + | **[[7lwr]] – Ter – Enterobacteria phage P21<br /> | ||
*Terminase large subunit | *Terminase large subunit | ||
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**[[4zni]], [[4znk]] – P74Ter ATPase domain <br /> | **[[4zni]], [[4znk]] – P74Ter ATPase domain <br /> | ||
**[[4znj]] – P74Ter ATPase domain (mutant)<br /> | **[[4znj]] – P74Ter ATPase domain (mutant)<br /> | ||
| - | **[[ | + | **[[6z6d]], [[6z6e]] – Ter – ''E. coli'' virus H97 <br /> |
*Terminase large subunit complex | *Terminase large subunit complex | ||
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**[[5oeb]] – D6eTer + ADP <br /> | **[[5oeb]] – D6eTer + ADP <br /> | ||
**[[6vi1]], [[6xmi]] – Ter + antibody – Salmonella phage P22<br /> | **[[6vi1]], [[6xmi]] – Ter + antibody – Salmonella phage P22<br /> | ||
| + | **[[4znl]] – P74Ter ATPase domain + ADP <br /> | ||
| + | **[[7ks4]] – TpTer ATPase domain + ADP <br /> | ||
*Tripartite terminase | *Tripartite terminase | ||
Revision as of 08:50, 19 April 2022
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3D Structures of terminase
Updated on 19-April-2022
References
- ↑ PMID:22297528
- ↑ Sankhala RS, Lokareddy RK, Cingolani G. Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J Biol Chem. 2016 Mar 31. pii: jbc.M116.724393. PMID:27033706 doi:http://dx.doi.org/10.1074/jbc.M116.724393
- ↑ Heming JD, Huffman JB, Jones LM, Homa FL. Isolation and characterization of the herpes simplex virus 1 terminase complex. J Virol. 2014 Jan;88(1):225-36. doi: 10.1128/JVI.02632-13. Epub 2013 Oct 23. PMID:24155374 doi:http://dx.doi.org/10.1128/JVI.02632-13
- ↑ Zhao H, Christensen TE, Kamau YN, Tang L. Structures of the phage Sf6 large terminase provide new insights into DNA translocation and cleavage. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8075-8080. Epub 2013 Apr 29. PMID:23630261 doi:10.1073/pnas.1301133110
