7ns7
From Proteopedia
(Difference between revisions)
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==Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)== | ==Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)== | ||
| - | <StructureSection load='7ns7' size='340' side='right'caption='[[7ns7]]' scene=''> | + | <StructureSection load='7ns7' size='340' side='right'caption='[[7ns7]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NS7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ns7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NS7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ns7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ns7 OCA], [https://pdbe.org/7ns7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ns7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ns7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ns7 ProSAT]</span></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ns7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ns7 OCA], [https://pdbe.org/7ns7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ns7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ns7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ns7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[https://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cellini B]] | + | [[Category: Cellini, B]] |
| - | [[Category: Dindo M]] | + | [[Category: Dindo, M]] |
| + | [[Category: Alanine-glyoxylate aminotransferase]] | ||
| + | [[Category: Alanine-glyoxylate transaminase]] | ||
| + | [[Category: Alanine-glyoxylic aminotransferase]] | ||
| + | [[Category: Disorder]] | ||
| + | [[Category: L-alanine-glycine transaminase]] | ||
| + | [[Category: Pyrodoxal]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 03:06, 21 April 2022
Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)
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