This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7ns7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)== | ==Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)== | ||
| - | <StructureSection load='7ns7' size='340' side='right'caption='[[7ns7]]' scene=''> | + | <StructureSection load='7ns7' size='340' side='right'caption='[[7ns7]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NS7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ns7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NS7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ns7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ns7 OCA], [https://pdbe.org/7ns7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ns7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ns7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ns7 ProSAT]</span></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ns7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ns7 OCA], [https://pdbe.org/7ns7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ns7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ns7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ns7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[https://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cellini B]] | + | [[Category: Cellini, B]] |
| - | [[Category: Dindo M]] | + | [[Category: Dindo, M]] |
| + | [[Category: Alanine-glyoxylate aminotransferase]] | ||
| + | [[Category: Alanine-glyoxylate transaminase]] | ||
| + | [[Category: Alanine-glyoxylic aminotransferase]] | ||
| + | [[Category: Disorder]] | ||
| + | [[Category: L-alanine-glycine transaminase]] | ||
| + | [[Category: Pyrodoxal]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 03:06, 21 April 2022
Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)
| |||||||||||
