7s5a
From Proteopedia
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==Crystal structure of human chemokine CCL8== | ==Crystal structure of human chemokine CCL8== | ||
| - | <StructureSection load='7s5a' size='340' side='right'caption='[[7s5a]]' scene=''> | + | <StructureSection load='7s5a' size='340' side='right'caption='[[7s5a]], [[Resolution|resolution]] 1.37Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S5A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7s5a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S5A FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s5a OCA], [https://pdbe.org/7s5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s5a RCSB], [https://www.ebi.ac.uk/pdbsum/7s5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s5a ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s5a OCA], [https://pdbe.org/7s5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s5a RCSB], [https://www.ebi.ac.uk/pdbsum/7s5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s5a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/CCL8_HUMAN CCL8_HUMAN]] Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.<ref>PMID:9558113</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects requires structural understanding of their target selectivity. Structures of the class A evasin EVA-P974 bound to human CC chemokine ligands 7 and 17 (CCL7 and CCL17) and to a CCL8-CCL7 chimera reveal that the specificity of class A evasins for chemokines of the CC subfamily is defined by conserved, rigid backbone-backbone interactions, whereas the preference for a subset of CC chemokines is controlled by side-chain interactions at four hotspots in flexible structural elements. Hotspot mutations alter target preference, enabling inhibition of selected chemokines. The structure of an engineered EVA-P974 bound to CCL2 reveals an underlying molecular mechanism of EVA-P974 target preference. These results provide a structure-based framework for engineering evasins as targeted antiinflammatory therapeutics. | ||
| + | |||
| + | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases.,Bhusal RP, Aryal P, Devkota SR, Pokhrel R, Gunzburg MJ, Foster SR, Lim HD, Payne RJ, Wilce MCJ, Stone MJ Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). pii: 2122105119. doi:, 10.1073/pnas.2122105119. PMID:35217625<ref>PMID:35217625</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7s5a" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Aryal P]] | + | [[Category: Aryal, P]] |
| - | [[Category: Bhusal | + | [[Category: Bhusal, R P]] |
| - | [[Category: Devkota | + | [[Category: Devkota, S R]] |
| - | [[Category: Stone | + | [[Category: Stone, M J]] |
| - | [[Category: Wilce | + | [[Category: Wilce, M C.J]] |
| + | [[Category: Cc chemokine]] | ||
| + | [[Category: Cytokine]] | ||
Revision as of 03:08, 21 April 2022
Crystal structure of human chemokine CCL8
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