1gxp

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[[Image:1gxp.gif|left|200px]]
[[Image:1gxp.gif|left|200px]]
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{{Structure
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|PDB= 1gxp |SIZE=350|CAPTION= <scene name='initialview01'>1gxp</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1gxp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gxp| PDB=1gxp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxp OCA], [http://www.ebi.ac.uk/pdbsum/1gxp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gxp RCSB]</span>
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'''PHOB EFFECTOR DOMAIN IN COMPLEX WITH PHO BOX DNA.'''
'''PHOB EFFECTOR DOMAIN IN COMPLEX WITH PHO BOX DNA.'''
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[[Category: Gomis-Ruth, F X.]]
[[Category: Gomis-Ruth, F X.]]
[[Category: Sola, M.]]
[[Category: Sola, M.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: dna binding]]
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[[Category: Dna binding]]
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[[Category: helix-winged-helix]]
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[[Category: Helix-winged-helix]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: sensory transduction]]
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[[Category: Sensory transduction]]
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[[Category: transcriptional activator]]
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[[Category: Transcriptional activator]]
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[[Category: two-component signal transduction]]
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[[Category: Two-component signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:09:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:53:32 2008''
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Revision as of 15:09, 2 May 2008

Image:1gxp.gif

Template:STRUCTURE 1gxp

PHOB EFFECTOR DOMAIN IN COMPLEX WITH PHO BOX DNA.


Overview

PhoB is a signal transduction response regulator that activates nearly 40 genes in phosphate depletion conditions in E. coli and closely related bacteria. The structure of the PhoB effector domain in complex with its target DNA sequence, or pho box, reveals a novel tandem arrangement in which several monomers bind head to tail to successive 11-base pair direct-repeat sequences, coating one face of a smoothly bent double helix. The protein has a winged helix fold in which the DNA recognition elements comprise helix alpha 3, penetrating the major groove, and a beta hairpin wing interacting with a compressed minor groove via Arg219, tightly sandwiched between the DNA sugar backbones. The transactivation loops protrude laterally in an appropriate orientation to interact with the RNA polymerase sigma(70) subunit, which triggers transcription initiation.

About this Structure

1GXP is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator., Blanco AG, Sola M, Gomis-Ruth FX, Coll M, Structure. 2002 May;10(5):701-13. PMID:12015152 Page seeded by OCA on Fri May 2 18:09:06 2008

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OCA

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