3idw

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==Crystal structure of Sla1 homology domain 2==
==Crystal structure of Sla1 homology domain 2==
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<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='3idw' size='340' side='right'caption='[[3idw]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://pdbe.org/3idw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [https://pdbe.org/3idw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [https://www.ebi.ac.uk/pdbsum/3idw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST]] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>
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[[https://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST]] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/3idw_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/3idw_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Atcc 18824]]
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[[Category: Large Structures]]
[[Category: Bowie, J U]]
[[Category: Bowie, J U]]
[[Category: Cascio, D]]
[[Category: Cascio, D]]

Revision as of 03:30, 21 April 2022

Crystal structure of Sla1 homology domain 2

PDB ID 3idw

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