3ihj

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==Human alanine aminotransferase 2 in complex with PLP==
==Human alanine aminotransferase 2 in complex with PLP==
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<StructureSection load='3ihj' size='340' side='right' caption='[[3ihj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3ihj' size='340' side='right'caption='[[3ihj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ihj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IHJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ihj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPT2, AAT2, ALT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPT2, AAT2, ALT2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_transaminase Alanine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.2 2.6.1.2] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alanine_transaminase Alanine transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.2 2.6.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihj OCA], [http://pdbe.org/3ihj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihj RCSB], [http://www.ebi.ac.uk/pdbsum/3ihj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihj OCA], [https://pdbe.org/3ihj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihj RCSB], [https://www.ebi.ac.uk/pdbsum/3ihj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ALAT2_HUMAN ALAT2_HUMAN]] Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.<ref>PMID:11863375</ref>
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[[https://www.uniprot.org/uniprot/ALAT2_HUMAN ALAT2_HUMAN]] Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.<ref>PMID:11863375</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Aminotransferase|Aminotransferase]]
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Alanine transaminase]]
[[Category: Alanine transaminase]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Den]]
[[Category: Berg, S Van Den]]

Revision as of 03:32, 21 April 2022

Human alanine aminotransferase 2 in complex with PLP

PDB ID 3ihj

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