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3iwx

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==Crystal structure of cisplatin bound to a human copper chaperone (dimer)==
==Crystal structure of cisplatin bound to a human copper chaperone (dimer)==
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<StructureSection load='3iwx' size='340' side='right' caption='[[3iwx]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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<StructureSection load='3iwx' size='340' side='right'caption='[[3iwx]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3iwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3iwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iwl|3iwl]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iwl|3iwl]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwx OCA], [http://pdbe.org/3iwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwx RCSB], [http://www.ebi.ac.uk/pdbsum/3iwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwx OCA], [https://pdbe.org/3iwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwx RCSB], [https://www.ebi.ac.uk/pdbsum/3iwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
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[[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Boal, A K]]
[[Category: Boal, A K]]
[[Category: Rosenzweig, A C]]
[[Category: Rosenzweig, A C]]

Revision as of 03:44, 21 April 2022

Crystal structure of cisplatin bound to a human copper chaperone (dimer)

PDB ID 3iwx

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