Sphingosine kinase
From Proteopedia
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==Structure== | ==Structure== | ||
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| - | <scene name='91/910628/Sphingosine_kinasee/1'>Sphingosine Kinase Trimer</scene> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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</StructureSection> | </StructureSection> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 18:05, 22 April 2022
Contents |
Structure
Function
Sphingolipids are a class of lipids, containing a sphingosine base moiety, essential for eukaryotic (host) cell membrane structure and function. [1] Importantly, sphingolipids can additionally act as critical signaling molecules used in many homeostatic cellular processes, such as inflammation, proliferation, apoptosis, cell migration, and pathogen defense. [1] Thus, it is critical for sphingolipids and their metabolizing enzymes to exist in a delicate homeostatic balance within the host.
Sphingosine-1-Phosphate (S1P), a lipid within the sphingolipid class, is an important signaling molecule that can participate in intracellular and extracellular signaling. [1] [2] S1P is critical not only to intracellular eukaryotic cell survival and function but is pivotal to eliciting the immune response, particularly as a mechanism to pathogen defense. [2] Sphingosine Kinase, existing in two isoenzyme forms, SphK1 and SphK2, creates S1P via the phosphorylation of sphingosine, the base moiety of all sphingolipids. [2]
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
References
- ↑ 1.0 1.1 1.2 Futerman AH, Hannun YA. The complex life of simple sphingolipids. EMBO Rep. 2004 Aug;5(8):777-82. doi: 10.1038/sj.embor.7400208. PMID:15289826 doi:http://dx.doi.org/10.1038/sj.embor.7400208
- ↑ 2.0 2.1 2.2 Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003 May;4(5):397-407. doi: 10.1038/nrm1103. PMID:12728273 doi:http://dx.doi.org/10.1038/nrm1103
