Sphingosine kinase
From Proteopedia
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==Structure== | ==Structure== | ||
| + | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
'''Sphingolipids''' are a class of lipids, containing a sphingosine base moiety, essential for eukaryotic (host) cell membrane structure and function. <ref name="futerman">PMID:15289826</ref> Importantly, sphingolipids can additionally act as critical signaling molecules used in many homeostatic cellular processes, such as inflammation, proliferation, apoptosis, cell migration, and '''pathogen defense'''. <ref name="futerman">PMID:15289826</ref> Thus, it is critical for sphingolipids and their metabolizing enzymes to exist in a delicate homeostatic balance within the host. | '''Sphingolipids''' are a class of lipids, containing a sphingosine base moiety, essential for eukaryotic (host) cell membrane structure and function. <ref name="futerman">PMID:15289826</ref> Importantly, sphingolipids can additionally act as critical signaling molecules used in many homeostatic cellular processes, such as inflammation, proliferation, apoptosis, cell migration, and '''pathogen defense'''. <ref name="futerman">PMID:15289826</ref> Thus, it is critical for sphingolipids and their metabolizing enzymes to exist in a delicate homeostatic balance within the host. | ||
| - | '''Sphingosine-1-Phosphate (S1P)''', a lipid within the sphingolipid class, is an important signaling molecule that can participate in intracellular and extracellular signaling. <ref name="futerman">PMID:15289826</ref> <ref | + | '''Sphingosine-1-Phosphate (S1P)''', a lipid within the sphingolipid class, is an important signaling molecule that can participate in intracellular and extracellular signaling. <ref name="futerman">PMID:15289826</ref> <ref>PMID:12728273</ref> S1P is critical not only to intracellular eukaryotic cell survival and function but is pivotal to eliciting the immune response, particularly as a mechanism to pathogen defense. <ref>PMID:12728273</ref> '''Sphingosine Kinase''', existing in two isoenzyme forms, SphK1 and SphK2, '''creates S1P via the phosphorylation of sphingosine''', the base moiety of all sphingolipids. <ref>PMID:12728273</ref> |
Revision as of 18:11, 22 April 2022
Structure
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References
- ↑ 1.0 1.1 1.2 Futerman AH, Hannun YA. The complex life of simple sphingolipids. EMBO Rep. 2004 Aug;5(8):777-82. doi: 10.1038/sj.embor.7400208. PMID:15289826 doi:http://dx.doi.org/10.1038/sj.embor.7400208
- ↑ Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003 May;4(5):397-407. doi: 10.1038/nrm1103. PMID:12728273 doi:http://dx.doi.org/10.1038/nrm1103
- ↑ Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003 May;4(5):397-407. doi: 10.1038/nrm1103. PMID:12728273 doi:http://dx.doi.org/10.1038/nrm1103
- ↑ Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003 May;4(5):397-407. doi: 10.1038/nrm1103. PMID:12728273 doi:http://dx.doi.org/10.1038/nrm1103
