Thymidine kinase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The biological assembly of Thymidine kinase is <scene name='45/455455/Cv/5'>homotetramer</scene>. <scene name='45/455455/Cv/6'>Thymidine and phosphate are bound in the hydrophobic active site pocket of TK</scene><ref>PMID:17288553</ref>. Water molecules are shown as red spheres. | The biological assembly of Thymidine kinase is <scene name='45/455455/Cv/5'>homotetramer</scene>. <scene name='45/455455/Cv/6'>Thymidine and phosphate are bound in the hydrophobic active site pocket of TK</scene><ref>PMID:17288553</ref>. Water molecules are shown as red spheres. | ||
| + | == 3D Structures of thymidine kinase == | ||
| + | [[Thymidine kinase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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*Thymidine kinase complex with reactants or products | *Thymidine kinase complex with reactants or products | ||
| - | + | **[[1e2i]] - HsvTK 46-376 + hydroxypropyladenine<BR /> | |
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| - | **[[1e2i]] - HsvTK + hydroxypropyladenine<BR /> | + | |
**[[1e2j]] - HsvTK (mutant) + THM<BR /> | **[[1e2j]] - HsvTK (mutant) + THM<BR /> | ||
**[[1kim]] - HsvTK + THM<BR /> | **[[1kim]] - HsvTK + THM<BR /> | ||
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**[[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR /> | **[[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR /> | ||
**[[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR /> | **[[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR /> | ||
| - | **[[1p6x]] – EhvTK + THM – Equine Herpes virus 4<BR /> | ||
**[[4uxh]], [[4uxi]], [[4uxj]] – TK + thymidine derivative – ''Leishmania major''<br /> | **[[4uxh]], [[4uxi]], [[4uxj]] – TK + thymidine derivative – ''Leishmania major''<br /> | ||
| + | **[[1p6x]] – EhvTK 23-352 + THM – Equine Herpes virus 4<BR /> | ||
**[[1p72]] - EhvTK + THM + ADP<BR /> | **[[1p72]] - EhvTK + THM + ADP<BR /> | ||
**[[2qqe]] – TmTK + THM<BR /> | **[[2qqe]] – TmTK + THM<BR /> | ||
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**[[2j9r]] – TK + THM – ''Bacillus anthracis''<BR /> | **[[2j9r]] – TK + THM – ''Bacillus anthracis''<BR /> | ||
**[[1xx6]] – TK + ADP – ''Clostridium acetobutylicum''<br /> | **[[1xx6]] – TK + ADP – ''Clostridium acetobutylicum''<br /> | ||
| - | **[[5fuv]] – TbTK + THM – ''Trypanosoma brucei''<br /> | + | **[[5fuv]] – TbTK catalytic domain 204-383 + THM – ''Trypanosoma brucei''<br /> |
| - | **[[5fuw]] – TbTK + THM + DTMP<br /> | + | **[[5fuw]] – TbTK catalytic domain + THM + DTMP<br /> |
| - | **[[5fux]], [[5fuy]] – TbTK (mutation) + DTMP<br /> | + | **[[5fux]], [[5fuy]] – TbTK catalytic domain (mutation) + DTMP<br /> |
*Thymidine kinase complex with feed-back inhibitor | *Thymidine kinase complex with feed-back inhibitor | ||
| - | **[[1oe0]], [[2vp0]], [[2jcs]] – DmTK + dTTP <br /> | ||
| - | **[[1zm7]] – DmTK (mutant) + dTTP <br /> | ||
**[[2j87]] – TK + TTP – Vaccinia virus<BR /> | **[[2j87]] – TK + TTP – Vaccinia virus<BR /> | ||
**[[2uz3]] – TK (mutant) + TTP – ''Ureaplasma urealyticum''<BR /> | **[[2uz3]] – TK (mutant) + TTP – ''Ureaplasma urealyticum''<BR /> | ||
Revision as of 08:35, 24 April 2022
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3D Structures of thymidine kinase
Updated on 24-April-2022
References
- ↑ Perez-Perez MJ, Priego EM, Hernandez AI, Familiar O, Camarasa MJ, Negri A, Gago F, Balzarini J. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future. Med Res Rev. 2008 Sep;28(5):797-820. doi: 10.1002/med.20124. PMID:18459168 doi:http://dx.doi.org/10.1002/med.20124
- ↑ He Q, Zhang P, Zou L, Li H, Wang X, Zhou S, Fornander T, Skog S. Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. Oncol Rep. 2005 Oct;14(4):1013-9. PMID:16142366
- ↑ Saada A, Shaag A, Mandel H, Nevo Y, Eriksson S, Elpeleg O. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet. 2001 Nov;29(3):342-4. PMID:11687801 doi:http://dx.doi.org/10.1038/ng751
- ↑ Kosinska U, Carnrot C, Sandrini MP, Clausen AR, Wang L, Piskur J, Eriksson S, Eklund H. Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding. FEBS J. 2007 Feb;274(3):727-37. PMID:17288553 doi:10.1111/j.1742-4658.2006.05617.x
