1gyk

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[[Image:1gyk.gif|left|200px]]
[[Image:1gyk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1gyk |SIZE=350|CAPTION= <scene name='initialview01'>1gyk</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1gyk", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CA1:Ca+Binding+Site+For+Chain+E'>CA1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CDG:METHYL+4,6-O-[(1R)-1-CARBOXYETHYLIDENE]-BETA-D-GALACTOPYRANOSIDE'>CDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gyk| PDB=1gyk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyk OCA], [http://www.ebi.ac.uk/pdbsum/1gyk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gyk RCSB]</span>
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}}
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'''SERUM AMYLOID P COMPONENT CO-CRYSTALLISED WITH MOBDG AT NEUTRAL PH'''
'''SERUM AMYLOID P COMPONENT CO-CRYSTALLISED WITH MOBDG AT NEUTRAL PH'''
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[[Category: Tickle, I.]]
[[Category: Tickle, I.]]
[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
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[[Category: amyloid lectin]]
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[[Category: Amyloid lectin]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: pentraxin]]
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[[Category: Pentraxin]]
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[[Category: plasma]]
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[[Category: Plasma]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:11:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:53:59 2008''
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Revision as of 15:11, 2 May 2008

Image:1gyk.gif

Template:STRUCTURE 1gyk

SERUM AMYLOID P COMPONENT CO-CRYSTALLISED WITH MOBDG AT NEUTRAL PH


Overview

Two monoclinic (P2(1)) crystal forms of human serum amyloid P component (SAP) in complex with the 4,6-pyruvate acetal of beta-D-galactose (MObetaDG) were prepared. Structure analysis by molecular replacement and refinement at 2.2A resolution revealed that crystal form 1 (a=95.76A, b=70.53A, c=103.41A, beta=96.80 degrees) contained a pentamer in the asymmetric unit with a structure very similar to that of the published search model. The mode of ligand co-ordination was also similar except that four of the five subunits showed bound ligand with an additional H-bond between O1 of the galactose and the side-chain of Lys79. One sub-unit showed no bound ligand and a vacant calcium site close to a crystal contact. The 2.6A resolution structure of crystal form 2 (a=118.60A, b=109.10A, c=120.80A and beta=95.16 degrees ) showed ten sub-units in the asymmetric unit, all with two bound calcium ions and ligand. The most extensive protein-protein interactions between pentamers describe an AB face-to-face interaction involving 15 ion pairs that sandwiches five molecules of bound MObetaDG at the interface.

About this Structure

1GYK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose., Thompson D, Pepys MB, Tickle I, Wood S, J Mol Biol. 2002 Jul 26;320(5):1081-6. PMID:12126626 Page seeded by OCA on Fri May 2 18:11:00 2008

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