1gz0
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1gz0.jpg|left|200px]] | [[Image:1gz0.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1gz0", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1gz0| PDB=1gz0 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB''' | '''23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB''' | ||
| Line 29: | Line 26: | ||
[[Category: Michel, G.]] | [[Category: Michel, G.]] | ||
[[Category: 2'o-methyltransferase]] | [[Category: 2'o-methyltransferase]] | ||
| - | [[Category: | + | [[Category: Bsgi]] |
| - | [[Category: | + | [[Category: Knot]] |
| - | [[Category: | + | [[Category: Methyltransferase]] |
| - | [[Category: | + | [[Category: Montreal-kingston bacterial structural genomics initiative]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:11:50 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:11, 2 May 2008
23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB
Overview
In Escherichia coli, RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. The crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution. RlmB consists of an N-terminal domain connected by a flexible extended linker to a catalytic C-terminal domain and forms a dimer in solution. The C-terminal domain displays a divergent methyltransferase fold with a unique knotted region, and lacks the classic AdoMet binding site features. The N-terminal domain is similar to ribosomal proteins L7 and L30, suggesting a role in 23S rRNA recognition. The conserved residues in this novel family of 2'O-methyltransferases cluster in the knotted region, suggesting the location of the catalytic and AdoMet binding sites.
About this Structure
1GZ0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot., Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M, Structure. 2002 Oct;10(10):1303-15. PMID:12377117 Page seeded by OCA on Fri May 2 18:11:50 2008
