Intracrine signaling
From Proteopedia
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<StructureSection load='1bwx' size='340' side='right' caption='Human parathyroid hormone fragment hPTH (1-39); [[1bwx]]' scene=''> | <StructureSection load='1bwx' size='340' side='right' caption='Human parathyroid hormone fragment hPTH (1-39); [[1bwx]]' scene=''> | ||
Intracrine refers to a hormone that acts inside a cell, regulating intracellular events. In simple terms it means that the cell stimulates itself by cellular production of a factor that acts within the cell. Steroid hormones act through intracellular (mostly nuclear) receptors and, thus, may be considered to be intracrines. | Intracrine refers to a hormone that acts inside a cell, regulating intracellular events. In simple terms it means that the cell stimulates itself by cellular production of a factor that acts within the cell. Steroid hormones act through intracellular (mostly nuclear) receptors and, thus, may be considered to be intracrines. | ||
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| + | There are several protein/peptide hormones that are also intracrines. Notable examples that have been described in the references include: | ||
| + | *Peptides of the renin–angiotensin system: angiotensin II and angiotensin (1-7) | ||
| + | *Fibroblast growth factor 2 | ||
| + | *Parathyroid hormone-related protein | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:29, 27 April 2022
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