7qut
From Proteopedia
(Difference between revisions)
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==serial synchrotron crystallographic structure of Drosophila Melanogaster (6-4) photolyase== | ==serial synchrotron crystallographic structure of Drosophila Melanogaster (6-4) photolyase== | ||
| - | <StructureSection load='7qut' size='340' side='right'caption='[[7qut]]' scene=''> | + | <StructureSection load='7qut' size='340' side='right'caption='[[7qut]], [[Resolution|resolution]] 2.24Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qut]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qut OCA], [https://pdbe.org/7qut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qut RCSB], [https://www.ebi.ac.uk/pdbsum/7qut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qut ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qut OCA], [https://pdbe.org/7qut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qut RCSB], [https://www.ebi.ac.uk/pdbsum/7qut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qut ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We present the structure of a photoactivated animal (6-4) photolyase in its radical pair state, captured by serial crystallography. We observe how a conserved asparigine moves towards the semiquinone FAD chromophore and stabilizes it by hydrogen bonding. Several amino acids around the final tryptophan radical rearrange, opening it up to the solvent. The structure explains how the protein environment stabilizes the radical pair state, which is crucial for function of (6-4) photolyases and cryptochromes. | ||
| + | |||
| + | Structural basis of the radical pair state in photolyases and cryptochromes.,Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, Wranik M, Aumonier S, Beale EV, Dworkowski F, Standfuss J, Weinert T, Westenhoff S Chem Commun (Camb). 2022 Mar 30. doi: 10.1039/d2cc00376g. PMID:35352724<ref>PMID:35352724</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7qut" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cellini A]] | + | [[Category: Cellini, A]] |
| - | [[Category: Kumar | + | [[Category: Kumar, M S]] |
| - | [[Category: Weixiao | + | [[Category: Weixiao, Y W]] |
| - | [[Category: Westenhoff S]] | + | [[Category: Westenhoff, S]] |
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Flavoprotein]] | ||
Revision as of 11:52, 27 April 2022
serial synchrotron crystallographic structure of Drosophila Melanogaster (6-4) photolyase
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