7tlm
From Proteopedia
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==Structure of Atopobium parvulum SufS== | ==Structure of Atopobium parvulum SufS== | ||
| - | <StructureSection load='7tlm' size='340' side='right'caption='[[7tlm]]' scene=''> | + | <StructureSection load='7tlm' size='340' side='right'caption='[[7tlm]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7tlm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tlm OCA], [https://pdbe.org/7tlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tlm RCSB], [https://www.ebi.ac.uk/pdbsum/7tlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tlm ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> |
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cysteine_desulfurase Cysteine desulfurase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.7 2.8.1.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tlm OCA], [https://pdbe.org/7tlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tlm RCSB], [https://www.ebi.ac.uk/pdbsum/7tlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tlm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/C8W9P2_LANP1 C8W9P2_LANP1]] Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.[RuleBase:RU004506] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Crohn's disease (CD) is characterized by the chronic inflammation of the gastrointestinal tract. A dysbiotic microbiome and a defective immune system are linked to CD, where hydrogen sulfide (H2 S) microbial producers positively correlate with the severity of the disease. Atopobium parvulum is a key H2 S producer from the microbiome of CD patients. In this study, the biochemical characterization of two Atopobium parvulum cysteine desulfurases, ApSufS and ApCsdB, shows that the enzymes are allosterically regulated. Structural analyses reveal that ApSufS forms a dimer with conserved characteristics observed in type II cysteine desulfurases. Four residues surrounding the active site are essential to catalyse cysteine desulfurylation, and a segment of short-chain residues grant access for substrate binding. A better understanding of ApSufS will help future avenues for CD treatment. | ||
| + | |||
| + | Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease.,Karunakaran G, Yang Y, Tremblay V, Ning Z, Martin J, Belaouad A, Figeys D, Brunzelle JS, Giguere PM, Stintzi A, Couture JF FEBS Lett. 2022 Feb 4. doi: 10.1002/1873-3468.14295. PMID:35122247<ref>PMID:35122247</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7tlm" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Selenocysteine lyase|Selenocysteine lyase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Cysteine desulfurase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Couture | + | [[Category: Couture, J F]] |
| - | [[Category: Karunakaran G]] | + | [[Category: Karunakaran, G]] |
| + | [[Category: Cysteine desulferase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 11:55, 27 April 2022
Structure of Atopobium parvulum SufS
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