This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1gzt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1gzt.gif|left|200px]]
[[Image:1gzt.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1gzt |SIZE=350|CAPTION= <scene name='initialview01'>1gzt</scene>, resolution 1.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_1gzt", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=FUA:Ca+Binding+Site+For+Chain+D'>FUA</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1gzt| PDB=1gzt | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [http://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB]</span>
+
-
}}
+
'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''
'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''
Line 28: Line 25:
[[Category: Imberty, A.]]
[[Category: Imberty, A.]]
[[Category: Mitchell, E.]]
[[Category: Mitchell, E.]]
-
[[Category: fucose]]
+
[[Category: Fucose]]
-
[[Category: lectin]]
+
[[Category: Lectin]]
-
[[Category: sugar-binding protein]]
+
[[Category: Sugar-binding protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:13:50 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:45 2008''
+

Revision as of 15:13, 2 May 2008

Image:1gzt.gif

Template:STRUCTURE 1gzt

PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE


Overview

Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.

About this Structure

1GZT is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289 Page seeded by OCA on Fri May 2 18:13:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gzt"
Personal tools