2xu5
From Proteopedia
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<StructureSection load='2xu5' size='340' side='right'caption='[[2xu5]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='2xu5' size='340' side='right'caption='[[2xu5]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xu5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XU5 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XU5:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]-1-[1-(4-METHYLPHENYL)CYCLOPROPYL]CARBONYL-PYRROLIDINE-2-CARBOXAMIDE'>XU5</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XU5:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]-1-[1-(4-METHYLPHENYL)CYCLOPROPYL]CARBONYL-PYRROLIDINE-2-CARBOXAMIDE'>XU5</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mhw|1mhw]], [[1cjl|1cjl]], [[1cs8|1cs8]], [[2vhs|2vhs]], [[1icf|1icf]], [[2xu4|2xu4]], [[2xu1|2xu1]], [[2xu3|2xu3]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mhw|1mhw]], [[1cjl|1cjl]], [[1cs8|1cs8]], [[2vhs|2vhs]], [[1icf|1icf]], [[2xu4|2xu4]], [[2xu1|2xu1]], [[2xu3|2xu3]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu5 OCA], [https://pdbe.org/2xu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xu5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes. |
==See Also== | ==See Also== | ||
Revision as of 12:17, 27 April 2022
CATHEPSIN L WITH A NITRILE INHIBITOR
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Categories: Cathepsin L | Human | Large Structures | Banner, D W | Benz, J M | Haap, W | Drug design | Hydrolase | Thiol protease
