1gzu

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[[Image:1gzu.jpg|left|200px]]
[[Image:1gzu.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1gzu |SIZE=350|CAPTION= <scene name='initialview01'>1gzu</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1gzu", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=NMA:Nmn+Binding+Site+For+Chain+C'>NMA</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase Nicotinamide-nucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1gzu| PDB=1gzu | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzu OCA], [http://www.ebi.ac.uk/pdbsum/1gzu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gzu RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE IN COMPLEX WITH NMN'''
'''CRYSTAL STRUCTURE OF HUMAN NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE IN COMPLEX WITH NMN'''
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==About this Structure==
==About this Structure==
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1GZU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1GRY. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZU OCA].
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1GZU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gry 1gry]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZU OCA].
==Reference==
==Reference==
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[[Category: Werner, E.]]
[[Category: Werner, E.]]
[[Category: Ziegler, M.]]
[[Category: Ziegler, M.]]
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[[Category: adenylyltransferase]]
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[[Category: Adenylyltransferase]]
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[[Category: nad biosynthesis]]
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[[Category: Nad biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:14:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:56 2008''
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Revision as of 15:14, 2 May 2008

Image:1gzu.jpg

Template:STRUCTURE 1gzu

CRYSTAL STRUCTURE OF HUMAN NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE IN COMPLEX WITH NMN


Overview

The final step in the biosynthesis of nicotinamide-adenine dinucleotide, a major coenzyme in cellular redox reactions and involved in intracellular signaling, is catalyzed by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT). The X-ray structure of human NMNAT in complex with nicotinamide mononucleotide was solved by the single-wavelength anomalous dispersion method at a resolution of 2.9 A. Human NMNAT is a symmetric hexamer whose subunit is formed by a large six-stranded parallel beta-sheet with helices on both sides. Human NMNAT displays a different oligomerization compared to the archaeal enzyme. The protein-nicotinamide mononucleotide interaction pattern provides insight into ligand binding in the human enzyme.

About this Structure

1GZU is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1gry. Full crystallographic information is available from OCA.

Reference

Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN., Werner E, Ziegler M, Lerner F, Schweiger M, Heinemann U, FEBS Lett. 2002 Apr 10;516(1-3):239-44. PMID:11959140 Page seeded by OCA on Fri May 2 18:14:04 2008

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OCA

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