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2yb9

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<StructureSection load='2yb9' size='340' side='right'caption='[[2yb9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2yb9' size='340' side='right'caption='[[2yb9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YB9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yb9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YB9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HA0:HETEROARYLALANINE+5-PHENYL+OXAZOLE'>HA0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HA0:HETEROARYLALANINE+5-PHENYL+OXAZOLE'>HA0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qvd|1qvd]], [[1y8j|1y8j]], [[1r1j|1r1j]], [[1dl9|1dl9]], [[1r1h|1r1h]], [[1dmt|1dmt]], [[1r1i|1r1i]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qvd|1qvd]], [[1y8j|1y8j]], [[1r1j|1r1j]], [[1dl9|1dl9]], [[1r1h|1r1h]], [[1dmt|1dmt]], [[1r1i|1r1i]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yb9 OCA], [http://pdbe.org/2yb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yb9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yb9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yb9 OCA], [https://pdbe.org/2yb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yb9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yb9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN]] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref>
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[[https://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN]] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 12:26, 27 April 2022

Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid.

PDB ID 2yb9

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