2yee
From Proteopedia
(Difference between revisions)
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<StructureSection load='2yee' size='340' side='right'caption='[[2yee]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2yee' size='340' side='right'caption='[[2yee]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yee]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEE FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2EC:9-ETHYL-9H-PURIN-6-YLAMINE'>2EC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2EC:9-ETHYL-9H-PURIN-6-YLAMINE'>2EC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yes|1yes]], [[1uy9|1uy9]], [[2cdd|2cdd]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[1uy8|1uy8]], [[2wi4|2wi4]], [[2bug|2bug]], [[2uwd|2uwd]], [[2wi7|2wi7]], [[2xhx|2xhx]], [[2bt0|2bt0]], [[1yer|1yer]], [[2xdu|2xdu]], [[1uyg|1uyg]], [[2bz5|2bz5]], [[2ccu|2ccu]], [[2xds|2xds]], [[2xdx|2xdx]], [[2xk2|2xk2]], [[2ccs|2ccs]], [[2xjj|2xjj]], [[1uyf|1uyf]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[1uyd|1uyd]], [[2byi|2byi]], [[2wi2|2wi2]], [[2xdl|2xdl]], [[1uy6|1uy6]], [[2vci|2vci]], [[2wi1|2wi1]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2xjx|2xjx]], [[2xdk|2xdk]], [[2fwz|2fwz]], [[2c2l|2c2l]], [[1uyh|1uyh]], [[2xjg|2xjg]], [[1uyk|1uyk]], [[2cct|2cct]], [[2fwy|2fwy]], [[1uyl|1uyl]], [[1uye|1uye]], [[2xab|2xab]], [[2wi6|2wi6]], [[1yc1|1yc1]], [[2xht|2xht]], [[1uyc|1uyc]], [[1uy7|1uy7]], [[2xhr|2xhr]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi5|2wi5]], [[2ye2|2ye2]], [[2ye9|2ye9]], [[2yeb|2yeb]], [[2ye7|2ye7]], [[2ye4|2ye4]], [[2yej|2yej]], [[2yec|2yec]], [[2ye5|2ye5]], [[2yea|2yea]], [[2yeh|2yeh]], [[2ye6|2ye6]], [[2yed|2yed]], [[2yei|2yei]], [[2yeg|2yeg]], [[2yef|2yef]], [[2ye8|2ye8]], [[2ye3|2ye3]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yes|1yes]], [[1uy9|1uy9]], [[2cdd|2cdd]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[1uy8|1uy8]], [[2wi4|2wi4]], [[2bug|2bug]], [[2uwd|2uwd]], [[2wi7|2wi7]], [[2xhx|2xhx]], [[2bt0|2bt0]], [[1yer|1yer]], [[2xdu|2xdu]], [[1uyg|1uyg]], [[2bz5|2bz5]], [[2ccu|2ccu]], [[2xds|2xds]], [[2xdx|2xdx]], [[2xk2|2xk2]], [[2ccs|2ccs]], [[2xjj|2xjj]], [[1uyf|1uyf]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[1uyd|1uyd]], [[2byi|2byi]], [[2wi2|2wi2]], [[2xdl|2xdl]], [[1uy6|1uy6]], [[2vci|2vci]], [[2wi1|2wi1]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2xjx|2xjx]], [[2xdk|2xdk]], [[2fwz|2fwz]], [[2c2l|2c2l]], [[1uyh|1uyh]], [[2xjg|2xjg]], [[1uyk|1uyk]], [[2cct|2cct]], [[2fwy|2fwy]], [[1uyl|1uyl]], [[1uye|1uye]], [[2xab|2xab]], [[2wi6|2wi6]], [[1yc1|1yc1]], [[2xht|2xht]], [[1uyc|1uyc]], [[1uy7|1uy7]], [[2xhr|2xhr]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi5|2wi5]], [[2ye2|2ye2]], [[2ye9|2ye9]], [[2yeb|2yeb]], [[2ye7|2ye7]], [[2ye4|2ye4]], [[2yej|2yej]], [[2yec|2yec]], [[2ye5|2ye5]], [[2yea|2yea]], [[2yeh|2yeh]], [[2ye6|2ye6]], [[2yed|2yed]], [[2yei|2yei]], [[2yeg|2yeg]], [[2yef|2yef]], [[2ye8|2ye8]], [[2ye3|2ye3]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yee OCA], [https://pdbe.org/2yee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yee RCSB], [https://www.ebi.ac.uk/pdbsum/2yee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yee ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> |
==See Also== | ==See Also== | ||
Revision as of 12:28, 27 April 2022
HSP90 inhibitors and drugs from fragment and virtual screening
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