2yf0
From Proteopedia
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<StructureSection load='2yf0' size='340' side='right'caption='[[2yf0]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='2yf0' size='340' side='right'caption='[[2yf0]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yf0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YF0 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yf0 OCA], [https://pdbe.org/2yf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2yf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yf0 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MTMR6_HUMAN MTMR6_HUMAN]] Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.<ref>PMID:15831468</ref> <ref>PMID:16847315</ref> |
==See Also== | ==See Also== | ||
Revision as of 12:28, 27 April 2022
Human Myotubularin related protein 6 (MTMR6)
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Categories: Human | Large Structures | Arrowsmith, C H | Berglund, H | Bountra, C | Collins, R | Edwards, A M | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, I | Karlberg, T | Kotenyova, T | Kouznetsova, E | Moche, M | Nordlund, P | Nyman, T | Persson, C | Schuler, H | Schutz, P | Siponen, M I | Thorsell, A G | Tresaugues, L | VanDenBerg, S | Wahlberg, E | Weigelt, J | Welin, M | Hydrolase
