2yhf

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<StructureSection load='2yhf' size='340' side='right'caption='[[2yhf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2yhf' size='340' side='right'caption='[[2yhf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yhf]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YHF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YHF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yhf]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YHF FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yhf OCA], [http://pdbe.org/2yhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yhf RCSB], [http://www.ebi.ac.uk/pdbsum/2yhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yhf ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yhf OCA], [https://pdbe.org/2yhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yhf RCSB], [https://www.ebi.ac.uk/pdbsum/2yhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yhf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLC5A_HUMAN CLC5A_HUMAN]] Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.<ref>PMID:10449773</ref> <ref>PMID:18496526</ref>
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[[https://www.uniprot.org/uniprot/CLC5A_HUMAN CLC5A_HUMAN]] Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.<ref>PMID:10449773</ref> <ref>PMID:18496526</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 12:30, 27 April 2022

1.9 Angstrom Crystal Structure of CLEC5A

PDB ID 2yhf

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