2yoq

From Proteopedia

(Difference between revisions)

Revision as of 12:34, 27 April 2022

Structure of FAM3B PANDER E30 construct

Structural highlights

2yoq is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	2yop
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FAM3B_MOUSE] Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.^[1]

Publication Abstract from PubMed

The FAM3 superfamily is predicted to contain classical four-helix bundle cytokines, featuring a typical up-up-down-down fold. Two members of FAM3 have been extensively studied. FAM3B PANDER has been shown to regulate glucose homeostasis and beta cell function, whereas the homologous FAM3C ILEI has been shown to be involved in epithelial-mesenchymal transition and cancer. Here, we present a three-dimensional structure of a FAM3 protein, murine PANDER. Contrary to previous suggestions, PANDER exhibits a globular beta-beta-alpha fold. The structure is composed of two antiparallel beta sheets lined by three short helices packing to form a highly conserved water-filled cavity. The fold shares no relation to the predicted four-helix cytokines but is conserved throughout the FAM3 superfamily. The available biological data and the unexpected new fold indicate that FAM3 PANDER and ILEI could represent a new structural class of signaling molecules, with a different mode of action compared to the traditional four-helix bundle cytokines.

FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold.,Johansson P, Bernstrom J, Gorman T, Oster L, Backstrom S, Schweikart F, Xu B, Xue Y, Schiavone LH Structure. 2013 Jan 15. pii: S0969-2126(12)00464-9. doi:, 10.1016/j.str.2012.12.009. PMID:23333428^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Johansson P, Bernstrom J, Gorman T, Oster L, Backstrom S, Schweikart F, Xu B, Xue Y, Schiavone LH. FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold. Structure. 2013 Jan 15. pii: S0969-2126(12)00464-9. doi:, 10.1016/j.str.2012.12.009. PMID:23333428 doi:http://dx.doi.org/10.1016/j.str.2012.12.009
↑ Johansson P, Bernstrom J, Gorman T, Oster L, Backstrom S, Schweikart F, Xu B, Xue Y, Schiavone LH. FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold. Structure. 2013 Jan 15. pii: S0969-2126(12)00464-9. doi:, 10.1016/j.str.2012.12.009. PMID:23333428 doi:http://dx.doi.org/10.1016/j.str.2012.12.009

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2yoq"

@@ Line 3: / Line 3: @@
 <StructureSection load='2yoq' size='340' side='right'caption='[[2yoq]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2yoq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YOQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2yoq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOQ FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yop|2yop]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yop|2yop]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoq OCA], [http://pdbe.org/2yoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yoq RCSB], [http://www.ebi.ac.uk/pdbsum/2yoq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoq ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoq OCA], [https://pdbe.org/2yoq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoq RCSB], [https://www.ebi.ac.uk/pdbsum/2yoq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoq ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FAM3B_MOUSE FAM3B_MOUSE]] Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.<ref>PMID:23333428</ref>
+[[https://www.uniprot.org/uniprot/FAM3B_MOUSE FAM3B_MOUSE]] Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.<ref>PMID:23333428</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

2yoq

From Proteopedia

Revision as of 12:34, 27 April 2022

Structure of FAM3B PANDER E30 construct

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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