Ceramidase
From Proteopedia
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| - | <StructureSection load='2zxc' size='340' side='right' caption="CerN bound to C2 Ceramide[[2zxc]]", [[Resolution|resolution]] 2.20Å' scene='91/910024/2zxc_ballstick/1'> | + | <StructureSection load='2zxc' size='340' side='right' caption="CerN bound to C2 Ceramide [[2zxc]]", [[Resolution|resolution]] 2.20Å' scene='91/910024/2zxc_ballstick/1'> |
== Function == | == Function == | ||
'''CerN''' is a secreted enzyme that catalyzes the cleavage of the sphingolipid[https://en.wikipedia.org/wiki/Sphingolipid] <scene name='91/910024/C16ceramide/1'>ceramide</scene> at the <scene name='91/910024/C16ceramide_nacyl/1'>N-acyl linkage</scene>, producing <scene name='91/910024/C16ceramide_cleaved/1'>sphingosine and a fatty acid</scene>.<ref>PMID:9603946</ref> <ref>PMID:19088069</ref> | '''CerN''' is a secreted enzyme that catalyzes the cleavage of the sphingolipid[https://en.wikipedia.org/wiki/Sphingolipid] <scene name='91/910024/C16ceramide/1'>ceramide</scene> at the <scene name='91/910024/C16ceramide_nacyl/1'>N-acyl linkage</scene>, producing <scene name='91/910024/C16ceramide_cleaved/1'>sphingosine and a fatty acid</scene>.<ref>PMID:9603946</ref> <ref>PMID:19088069</ref> | ||
Revision as of 22:58, 27 April 2022
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References
- ↑ Okino N, Tani M, Imayama S, Ito M. Purification and characterization of a novel ceramidase from Pseudomonas aeruginosa. J Biol Chem. 1998 Jun 5;273(23):14368-73. PMID:9603946
- ↑ Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M. Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J Biol Chem. 2009 Apr 3;284(14):9566-77. Epub 2008 Dec 16. PMID:19088069 doi:10.1074/jbc.M808232200
