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GLUT1
From Proteopedia
(Difference between revisions)
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===Cancer=== | ===Cancer=== | ||
| - | Oncogenes such as Ras and Src have been shown to upregulate GLUT1 in rat tumors. GLUT1 has also been consistently shown to be upregulated in malignancies of the breast.<ref>PMID:15389572</ref> Increased glucose utilization by upregulation of the GLUT1 transporter increases | + | Oncogenes such as Ras and Src have been shown to upregulate GLUT1 in rat tumors. GLUT1 has also been consistently shown to be upregulated in malignancies of the breast.<ref>PMID:15389572</ref> Increased glucose utilization by upregulation of the GLUT1 transporter increases cell proliferation in some types of breast cancer.<ref>PMID:27931517</ref> |
== Relevance == | == Relevance == | ||
Revision as of 03:04, 28 April 2022
Facilitated Glucose Transporter 1, Solute Carrier Family 2, Homo sapiens
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References
- ↑ Pragallapati S, Manyam R. Glucose transporter 1 in health and disease. J Oral Maxillofac Pathol. 2019 Sep-Dec;23(3):443-449. doi:, 10.4103/jomfp.JOMFP_22_18. PMID:31942129 doi:http://dx.doi.org/10.4103/jomfp.JOMFP_22_18
- ↑ Koepsell H. Glucose transporters in brain in health and disease. Pflugers Arch. 2020 Sep;472(9):1299-1343. doi: 10.1007/s00424-020-02441-x. Epub, 2020 Aug 13. PMID:32789766 doi:http://dx.doi.org/10.1007/s00424-020-02441-x
- ↑ Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol. 2005 Mar;202(3):654-62. doi: 10.1002/jcp.20166. PMID:15389572 doi:http://dx.doi.org/10.1002/jcp.20166
- ↑ Oh S, Kim H, Nam K, Shin I. Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cells. BMB Rep. 2017 Mar;50(3):132-137. doi: 10.5483/bmbrep.2017.50.3.189. PMID:27931517 doi:http://dx.doi.org/10.5483/bmbrep.2017.50.3.189
- ↑ Asano T, Katagiri H, Takata K, Lin JL, Ishihara H, Inukai K, Tsukuda K, Kikuchi M, Hirano H, Yazaki Y, et al.. The role of N-glycosylation of GLUT1 for glucose transport activity. J Biol Chem. 1991 Dec 25;266(36):24632-6. PMID:1761560
