1h09

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1h09.gif|left|200px]]
[[Image:1h09.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1h09 |SIZE=350|CAPTION= <scene name='initialview01'>1h09</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1h09", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1h09| PDB=1h09 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h09 OCA], [http://www.ebi.ac.uk/pdbsum/1h09 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h09 RCSB]</span>
+
-
}}
+
'''MULTIMODULAR PNEUMOCOCCAL CELL WALL ENDOLYSIN FROM PHAGE CP-1'''
'''MULTIMODULAR PNEUMOCOCCAL CELL WALL ENDOLYSIN FROM PHAGE CP-1'''
Line 33: Line 30:
[[Category: Menendez, M.]]
[[Category: Menendez, M.]]
[[Category: Monterroso, B.]]
[[Category: Monterroso, B.]]
-
[[Category: bacteriolytic enzyme]]
+
[[Category: Bacteriolytic enzyme]]
-
[[Category: glycosidase]]
+
[[Category: Glycosidase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: lysozyme]]
+
[[Category: Lysozyme]]
-
[[Category: multimodular]]
+
[[Category: Multimodular]]
-
[[Category: murein hydrolase]]
+
[[Category: Murein hydrolase]]
-
[[Category: pneumococcal cell wall degradation]]
+
[[Category: Pneumococcal cell wall degradation]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:01 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:55:07 2008''
+

Revision as of 15:15, 2 May 2008

Image:1h09.gif

Template:STRUCTURE 1h09

MULTIMODULAR PNEUMOCOCCAL CELL WALL ENDOLYSIN FROM PHAGE CP-1


Overview

Pneumococcal bacteriophage-encoded lysins are modular choline binding proteins that have been shown to act as enzymatic antimicrobial agents (enzybiotics) against streptococcal infections. Here we present the crystal structures of the free and choline bound states of the Cpl-1 lysin, encoded by the pneumococcal phage Cp-1. While the catalytic module displays an irregular (beta/alpha)(5)beta(3) barrel, the cell wall-anchoring module is formed by six similar choline binding repeats (ChBrs), arranged into two different structural regions: a left-handed superhelical domain configuring two choline binding sites, and a beta sheet domain that contributes in bringing together the whole structure. Crystallographic and site-directed mutagenesis studies allow us to propose a general catalytic mechanism for the whole glycoside hydrolase family 25. Our work provides the first complete structure of a member of the large family of choline binding proteins and reveals that ChBrs are versatile elements able to tune the evolution and specificity of the pneumococcal surface proteins.

About this Structure

1H09 is a Single protein structure of sequence from Bacteriophage cp-1. Full crystallographic information is available from OCA.

Reference

Structural basis for selective recognition of pneumococcal cell wall by modular endolysin from phage Cp-1., Hermoso JA, Monterroso B, Albert A, Galan B, Ahrazem O, Garcia P, Martinez-Ripoll M, Garcia JL, Menendez M, Structure. 2003 Oct;11(10):1239-49. PMID:14527392 Page seeded by OCA on Fri May 2 18:15:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h09"
Personal tools