1h0h

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[[Image:1h0h.gif|left|200px]]
[[Image:1h0h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1h0h |SIZE=350|CAPTION= <scene name='initialview01'>1h0h</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1h0h", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=WA:Fs4+Binding+Site+For+Chain+L'>WA</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2MD:GUANYLATE-O&#39;-PHOSPHORIC+ACID+MONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,5,6,7,8A,9,10,10A-OCTAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)+ESTER'>2MD</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSE:SELENOCYSTEINE'>CSE</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=S:SULFUR+ATOM'>S</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1h0h| PDB=1h0h | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0h OCA], [http://www.ebi.ac.uk/pdbsum/1h0h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h0h RCSB]</span>
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}}
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'''TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS'''
'''TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Raaijmakers, H C.A.]]
[[Category: Raaijmakers, H C.A.]]
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[[Category: iron-sulphur cluster]]
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[[Category: Iron-sulphur cluster]]
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[[Category: mgd]]
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[[Category: Mgd]]
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[[Category: molybdopterin]]
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[[Category: Molybdopterin]]
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[[Category: periplasmic]]
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[[Category: Periplasmic]]
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[[Category: selenocysteine]]
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[[Category: Selenocysteine]]
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[[Category: tungsten selenium formate dehydrogenase]]
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[[Category: Tungsten selenium formate dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:55:09 2008''
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Revision as of 15:15, 2 May 2008

Image:1h0h.gif

Template:STRUCTURE 1h0h

TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS


Overview

Desulfovibrio gigas formate dehydrogenase is the first representative of a tungsten-containing enzyme from a mesophile that has been structurally characterized. It is a heterodimer of 110 and 24 kDa subunits. The large subunit, homologous to E. coli FDH-H and to D. desulfuricans nitrate reductase, harbors the W site and one [4Fe-4S] center. No small subunit ortholog containing three [4Fe-4S] clusters has been reported. The structural homology with E. coli FDH-H shows that the essential residues (SeCys158, His159, and Arg407) at the active site are conserved. The active site is accessible via a positively charged tunnel, while product release may be facilitated, for H(+) by buried waters and protonable amino acids and for CO(2) through a hydrophobic channel.

About this Structure

1H0H is a Protein complex structure of sequences from Desulfovibrio gigas. Full crystallographic information is available from OCA.

Reference

Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas., Raaijmakers H, Macieira S, Dias JM, Teixeira S, Bursakov S, Huber R, Moura JJ, Moura I, Romao MJ, Structure. 2002 Sep;10(9):1261-72. PMID:12220497 Page seeded by OCA on Fri May 2 18:15:20 2008

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