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Interleukin receptor
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<StructureSection load='2b5i' size='340' side='right' caption='Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]]' scene=''> | <StructureSection load='2b5i' size='340' side='right' caption='Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]]' scene=''> | ||
| - | '''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | + | '''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). See also [[Interleukin]]. |
==3D structures of interleukin receptor== | ==3D structures of interleukin receptor== | ||
Revision as of 11:43, 1 May 2022
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