Autocrine signaling
From Proteopedia
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<StructureSection load='' size='350' side='right' scene='Vascular_Endothelial_Growth_Factor/Vegf-a_opening/1' caption='Structure of Human VEGF-A dimer, [[1vpf]]'> | <StructureSection load='' size='350' side='right' scene='Vascular_Endothelial_Growth_Factor/Vegf-a_opening/1' caption='Structure of Human VEGF-A dimer, [[1vpf]]'> | ||
Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. | Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. | ||
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| + | '''Interleukin-1''' | ||
An example of an autocrine agent is the cytokine interleukin-1 in monocytes (see [[Interleukin]]). When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it (see [[Interleukin receptors]]). | An example of an autocrine agent is the cytokine interleukin-1 in monocytes (see [[Interleukin]]). When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it (see [[Interleukin receptors]]). | ||
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| + | '''Wnt signaling pathway''' | ||
Normally, the [[Wnt signaling pathway]] leads to stabilization of β-catenin through inactivation of a protein complex containing the tumor suppressors [[Adenomatous polyposis coli]] (APC) and [[Axin]]. | Normally, the [[Wnt signaling pathway]] leads to stabilization of β-catenin through inactivation of a protein complex containing the tumor suppressors [[Adenomatous polyposis coli]] (APC) and [[Axin]]. | ||
Revision as of 13:52, 2 May 2022
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