1h15

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[[Image:1h15.gif|left|200px]]
[[Image:1h15.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1h15 |SIZE=350|CAPTION= <scene name='initialview01'>1h15</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1h15", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h15| PDB=1h15 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h15 OCA], [http://www.ebi.ac.uk/pdbsum/1h15 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h15 RCSB]</span>
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}}
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'''X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE'''
'''X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE'''
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[[Category: Svejgaard, A.]]
[[Category: Svejgaard, A.]]
[[Category: Wucherpfennig, K.]]
[[Category: Wucherpfennig, K.]]
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[[Category: class ii]]
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[[Category: Class ii]]
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[[Category: dna polymerase]]
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[[Category: Dna polymerase]]
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[[Category: dna-directed dna polymerase]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: dr2]]
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[[Category: Dr2]]
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[[Category: drb5]]
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[[Category: Drb5]]
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[[Category: ebv]]
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[[Category: Ebv]]
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[[Category: hla]]
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[[Category: Hla]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: peptide]]
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[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:17:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:55:35 2008''
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Revision as of 15:17, 2 May 2008

Image:1h15.gif

Template:STRUCTURE 1h15

X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE


Overview

The multiple sclerosis (MS)-associated HLA major histocompatibility complex (MHC) class II alleles DRB1*1501, DRB5*0101 and DQB1*0602 are in strong linkage disequilibrium, making it difficult to determine which is the principal MS risk gene. Here we show that together the DRB1 and DRB5 loci may influence susceptibility to MS. We demonstrate that a T cell receptor (TCR) from an MS patient recognized both a DRB1*1501-restricted myelin basic protein (MBP) and DRB5*0101-restricted Epstein-Barr virus (EBV) peptide. Crystal structure determination of the DRB5*0101-EBV peptide complex revealed a marked degree of structural equivalence to the DRB1*1501-MBP peptide complex at the surface presented for TCR recognition. This provides structural evidence for molecular mimicry involving HLA molecules. The structural details suggest an explanation for the preponderance of MHC class II associations in HLA-associated diseases.

About this Structure

1H15 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A functional and structural basis for TCR cross-reactivity in multiple sclerosis., Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L, Nat Immunol. 2002 Oct;3(10):940-3. Epub 2002 Sep 3. PMID:12244309 Page seeded by OCA on Fri May 2 18:17:10 2008

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OCA

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