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Autocrine signaling
From Proteopedia
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'''Wnt signaling pathway''' | '''Wnt signaling pathway''' | ||
| - | Normally, the [[Wnt signaling pathway]] leads to stabilization of β-catenin (see [[Catenin]]) through inactivation of a protein complex containing the tumor suppressors [[Adenomatous polyposis coli]] (APC) and [[Axin]]. Genetic alterations that lead to de-regulation of the autocrine Wnt pathway result in transactivation of [[Epidermal Growth Factor Receptor]] (EGFR) and other pathways, in turn contributing to proliferation of tumor cells. | + | Normally, the [[Wnt signaling pathway]] leads to stabilization of β-catenin (see [[Catenin]]) through inactivation of a protein complex containing the tumor suppressors [[Adenomatous polyposis coli]] (APC) and [[Axin]]. Genetic alterations that lead to de-regulation of the autocrine Wnt pathway result in transactivation of [[Epidermal Growth Factor Receptor]] (EGFR) and other pathways, in turn contributing to proliferation of tumor cells. |
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| + | '''Interleukin 6''' | ||
| + | *[[Interleukins]] | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 12:48, 4 May 2022
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