1h1t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1h1t.gif|left|200px]]
[[Image:1h1t.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1h1t |SIZE=350|CAPTION= <scene name='initialview01'>1h1t</scene>, resolution 1.78&Aring;
+
The line below this paragraph, containing "STRUCTURE_1h1t", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=COA:Pns+Binding+Site+For+Chain+B'>COA</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PNS:4&#39;-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1h1t| PDB=1h1t | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h1t OCA], [http://www.ebi.ac.uk/pdbsum/1h1t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h1t RCSB]</span>
+
-
}}
+
'''PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI'''
'''PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI'''
Line 27: Line 24:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Izard, T.]]
[[Category: Izard, T.]]
-
[[Category: coenzyme a biosynthesis]]
+
[[Category: Coenzyme a biosynthesis]]
-
[[Category: nucleotidyltransferase]]
+
[[Category: Nucleotidyltransferase]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:18:48 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:55:55 2008''
+

Revision as of 15:18, 2 May 2008

Image:1h1t.gif

Template:STRUCTURE 1h1t

PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI


Overview

Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg(2+):ATP to 4'-phosphopantetheine to form 3'-dephospho-CoA (dPCoA) and pyrophosphate. The high-resolution crystal structure of PPAT complexed with CoA has been determined. Remarkably, CoA and the product dPCoA bind to the active site in distinct ways. Although the phosphate moiety within the phosphopantetheine arm overlaps, the pantetheine arm binds to the same pocket in two distinct conformations, and the adenylyl moieties of these two ligands have distinct binding sites. Moreover, the PPAT:CoA crystal structure confirms the asymmetry of binding to the two trimers within the hexameric enzyme. Specifically, the pantetheine arm of CoA bound to one protomer within the asymmetric unit displays the dPCoA-like conformation with the adenylyl moiety disordered, whereas CoA binds the twofold-related protomer in an ordered and unique fashion.

About this Structure

1H1T is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A., Izard T, J Bacteriol. 2003 Jul;185(14):4074-80. PMID:12837781 Page seeded by OCA on Fri May 2 18:18:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h1t"
Personal tools