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6zx1
From Proteopedia
(Difference between revisions)
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==OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution== | ==OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution== | ||
| - | <StructureSection load='6zx1' size='340' side='right'caption='[[6zx1]]' scene=''> | + | <StructureSection load='6zx1' size='340' side='right'caption='[[6zx1]], [[Resolution|resolution]] 1.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZX1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zx1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZX1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zx1 OCA], [https://pdbe.org/6zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/6zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zx1 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UP6:6-AZA+URIDINE+5-MONOPHOSPHATE'>UP6</scene></td></tr> |
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zx1 OCA], [https://pdbe.org/6zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/6zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zx1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Krull M]] | + | [[Category: Krull, M]] |
| - | [[Category: Rindfleisch S]] | + | [[Category: Rindfleisch, S]] |
| - | [[Category: Tittmann K]] | + | [[Category: Tittmann, K]] |
| + | [[Category: Bmp]] | ||
| + | [[Category: Lyase]] | ||
| + | [[Category: Ompd]] | ||
| + | [[Category: Orotidine 5'-monophosphate decarboxylase]] | ||
| + | [[Category: Ump]] | ||
Revision as of 13:02, 4 May 2022
OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution
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