This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7otu
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2== | ==Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2== | ||
| - | <StructureSection load='7otu' size='340' side='right'caption='[[7otu]]' scene=''> | + | <StructureSection load='7otu' size='340' side='right'caption='[[7otu]], [[Resolution|resolution]] 0.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7otu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7otu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7otu OCA], [https://pdbe.org/7otu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7otu RCSB], [https://www.ebi.ac.uk/pdbsum/7otu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7otu ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7otu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7otu OCA], [https://pdbe.org/7otu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7otu RCSB], [https://www.ebi.ac.uk/pdbsum/7otu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7otu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Pappenheim, F Rabe von]] |
| - | [[Category: Rindfleisch S]] | + | [[Category: Rindfleisch, S]] |
| - | [[Category: Tittmann K]] | + | [[Category: Tittmann, K]] |
| + | [[Category: Bmp]] | ||
| + | [[Category: Lyase]] | ||
| + | [[Category: Ompd]] | ||
| + | [[Category: Orotidine 5'-monophosphate decarboxylase]] | ||
| + | [[Category: Ump]] | ||
Revision as of 13:05, 4 May 2022
Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2
| |||||||||||
