3j8g

<table><tr><td colspan='2'>[[3j8g]] is a 31 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J8G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J8G FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j8g OCA], [http://pdbe.org/3j8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j8g RCSB], [http://www.ebi.ac.uk/pdbsum/3j8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j8g ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/C9QXP2_ECOD1 C9QXP2_ECOD1]] This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).[HAMAP-Rule:MF_01366] [[http://www.uniprot.org/uniprot/C9QTZ1_ECOD1 C9QTZ1_ECOD1]] Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).[RuleBase:RU000560][HAMAP-Rule:MF_00382] [[http://www.uniprot.org/uniprot/C9QXG9_ECOD1 C9QXG9_ECOD1]] Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.[HAMAP-Rule:MF_01342] [[http://www.uniprot.org/uniprot/C9QXH3_ECOD1 C9QXH3_ECOD1]] One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity).[HAMAP-Rule:MF_01326] One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).[HAMAP-Rule:MF_01326] [[http://www.uniprot.org/uniprot/C9QRC1_ECOD1 C9QRC1_ECOD1]] This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.[HAMAP-Rule:MF_01336][SAAS:SAAS00023223] [[http://www.uniprot.org/uniprot/C9QTM2_ECOD1 C9QTM2_ECOD1]] Binds to the 23S rRNA.[HAMAP-Rule:MF_00503] [[http://www.uniprot.org/uniprot/H0QFK1_ECOLI H0QFK1_ECOLI]] Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.[HAMAP-Rule:MF_01318] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.[HAMAP-Rule:MF_01318] [[http://www.uniprot.org/uniprot/C9QXG7_ECOD1 C9QXG7_ECOD1]] The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity).[HAMAP-Rule:MF_01331] This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).[RuleBase:RU004008][HAMAP-Rule:MF_01331] [[http://www.uniprot.org/uniprot/C9QXH7_ECOD1 C9QXH7_ECOD1]] This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.[HAMAP-Rule:MF_01365][RuleBase:RU003870] [[http://www.uniprot.org/uniprot/C9QXG5_ECOD1 C9QXG5_ECOD1]] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.[HAMAP-Rule:MF_01320] [[http://www.uniprot.org/uniprot/C9QXH4_ECOD1 C9QXH4_ECOD1]] This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.[HAMAP-Rule:MF_01333] [[http://www.uniprot.org/uniprot/C9QXH8_ECOD1 C9QXH8_ECOD1]] This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.[HAMAP-Rule:MF_01337] [[http://www.uniprot.org/uniprot/C9QY61_ECOD1 C9QY61_ECOD1]] This protein binds to 23S rRNA in the presence of protein L20.[HAMAP-Rule:MF_01363][RuleBase:RU000562][SAAS:SAAS00030247] [[http://www.uniprot.org/uniprot/C9QXG2_ECOD1 C9QXG2_ECOD1]] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01325] [[http://www.uniprot.org/uniprot/B1X6G9_ECODH B1X6G9_ECODH]] One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.[HAMAP-Rule:MF_01369] [[http://www.uniprot.org/uniprot/C9QXG3_ECOD1 C9QXG3_ECOD1]] Forms part of the polypeptide exit tunnel (By similarity).[HAMAP-Rule:MF_01328] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).[HAMAP-Rule:MF_01328] [[http://www.uniprot.org/uniprot/C9QXH2_ECOD1 C9QXH2_ECOD1]] Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.[HAMAP-Rule:MF_01367][RuleBase:RU003950] [[http://www.uniprot.org/uniprot/C9R119_ECOD1 C9R119_ECOD1]] This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.[HAMAP-Rule:MF_00402][RuleBase:RU000559] [[http://www.uniprot.org/uniprot/C9QPR2_ECOD1 C9QPR2_ECOD1]] GTPase that plays an essential role in the late steps of ribosome biogenesis.[HAMAP-Rule:MF_00195][RuleBase:RU004481] [[http://www.uniprot.org/uniprot/C9QV94_ECOD1 C9QV94_ECOD1]] This protein binds directly to 23S ribosomal RNA (By similarity).[HAMAP-Rule:MF_00736][RuleBase:RU003979][SAAS:SAAS020785_004_002551] [[http://www.uniprot.org/uniprot/RL15_ECOLI RL15_ECOLI]] This protein binds the 5S rRNA. It is required for the late stages of subunit assembly, and is essential for 5S rRNA assembly onto the ribosome.[HAMAP-Rule:MF_01341_B]