3k7e
From Proteopedia
(Difference between revisions)
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==Crystal structure of human ligand-free mature caspase-6== | ==Crystal structure of human ligand-free mature caspase-6== | ||
| - | <StructureSection load='3k7e' size='340' side='right' caption='[[3k7e]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='3k7e' size='340' side='right'caption='[[3k7e]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3k7e]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3k7e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K7E FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cp3|1cp3]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cp3|1cp3]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k7e OCA], [https://pdbe.org/3k7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k7e RCSB], [https://www.ebi.ac.uk/pdbsum/3k7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k7e ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
==See Also== | ==See Also== | ||
| - | *[[Caspase|Caspase]] | + | *[[Caspase 3D structures|Caspase 3D structures]] |
*[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]] | *[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]] | ||
*[[Molecular Playground/Caspase-6 and neurodegeneration|Molecular Playground/Caspase-6 and neurodegeneration]] | *[[Molecular Playground/Caspase-6 and neurodegeneration|Molecular Playground/Caspase-6 and neurodegeneration]] | ||
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[[Category: Caspase-6]] | [[Category: Caspase-6]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hardy, J A]] | [[Category: Hardy, J A]] | ||
[[Category: Vaidya, S]] | [[Category: Vaidya, S]] | ||
Revision as of 13:33, 4 May 2022
Crystal structure of human ligand-free mature caspase-6
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Categories: Caspase-6 | Human | Large Structures | Hardy, J A | Vaidya, S | Apoptosis | Caspase | Hydrolase | Protease | Thiol protease | Zymogen
