3ldo
From Proteopedia
(Difference between revisions)
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==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with AMPPNP== | ==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with AMPPNP== | ||
- | <StructureSection load='3ldo' size='340' side='right' caption='[[3ldo]], [[Resolution|resolution]] 1.95Å' scene=''> | + | <StructureSection load='3ldo' size='340' side='right'caption='[[3ldo]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3ldo]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ldo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDO FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr> |
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ldl|3ldl]], [[3ldn|3ldn]], [[3ldp|3ldp]], [[3ldq|3ldq]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ldl|3ldl]], [[3ldn|3ldn]], [[3ldp|3ldp]], [[3ldq|3ldq]]</div></td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldo OCA], [https://pdbe.org/3ldo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldo RCSB], [https://www.ebi.ac.uk/pdbsum/3ldo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldo ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref> |
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.<ref>PMID:2294010</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3ldo" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3ldo" style="background-color:#fffaf0;"></div> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Dokurno, P]] | [[Category: Dokurno, P]] | ||
[[Category: Macias, A T]] | [[Category: Macias, A T]] |
Revision as of 13:39, 4 May 2022
Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with AMPPNP
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Categories: Human | Large Structures | Dokurno, P | Macias, A T | Massey, A J | Shaw, T | Surgenor, A E | Williamson, D S | Adenosine | Atp-binding | Chaperone | Endoplasmic reticulum | Grp78 | Heat shock | Hsc70 | Hsp70 | Nucleoside | Nucleotide-binding | Phosphoprotein | Protein folding | Selectivity | Small molecule inhibitor | Stress response