3ltl

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==Crystal structure of human BIG1 Sec7 domain==
==Crystal structure of human BIG1 Sec7 domain==
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<StructureSection load='3ltl' size='340' side='right' caption='[[3ltl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3ltl' size='340' side='right'caption='[[3ltl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ltl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ltl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LTL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARFGEF1, ARFGEP1, BIG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARFGEF1, ARFGEP1, BIG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltl OCA], [http://pdbe.org/3ltl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ltl RCSB], [http://www.ebi.ac.uk/pdbsum/3ltl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltl OCA], [https://pdbe.org/3ltl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ltl RCSB], [https://www.ebi.ac.uk/pdbsum/3ltl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BIG1_HUMAN BIG1_HUMAN]] Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.<ref>PMID:12571360</ref> <ref>PMID:15644318</ref> <ref>PMID:17227842</ref> <ref>PMID:22084092</ref> <ref>PMID:20360857</ref>
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[[https://www.uniprot.org/uniprot/BIG1_HUMAN BIG1_HUMAN]] Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.<ref>PMID:12571360</ref> <ref>PMID:15644318</ref> <ref>PMID:17227842</ref> <ref>PMID:22084092</ref> <ref>PMID:20360857</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Biou, V]]
[[Category: Biou, V]]
[[Category: Cherfils, J]]
[[Category: Cherfils, J]]

Revision as of 13:42, 4 May 2022

Crystal structure of human BIG1 Sec7 domain

PDB ID 3ltl

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