3m4t
From Proteopedia
(Difference between revisions)
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==Crystal structure of the BTB domain from Kaiso/ZBTB33, form I== | ==Crystal structure of the BTB domain from Kaiso/ZBTB33, form I== | ||
| - | <StructureSection load='3m4t' size='340' side='right' caption='[[3m4t]], [[Resolution|resolution]] 2.05Å' scene=''> | + | <StructureSection load='3m4t' size='340' side='right'caption='[[3m4t]], [[Resolution|resolution]] 2.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3m4t]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3m4t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4T FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m8v|3m8v]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3m8v|3m8v]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAISO, ZBTB33, ZNF348 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAISO, ZBTB33, ZNF348 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4t OCA], [https://pdbe.org/3m4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4t RCSB], [https://www.ebi.ac.uk/pdbsum/3m4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Chen, L]] | [[Category: Chen, L]] | ||
[[Category: Prive, G G]] | [[Category: Prive, G G]] | ||
Revision as of 13:43, 4 May 2022
Crystal structure of the BTB domain from Kaiso/ZBTB33, form I
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Categories: Human | Large Structures | Chen, L | Prive, G G | Stogios, P J | Activator | Btb domain | Btb/poz domain | Dna-binding | Kaiso | Metal-binding | Nucleus | Oligomeriation | Phosphoprotein | Poz domain | Protein-protein interaction domain | Repressor | Transcription | Transcription regulation | Transcriptional regulator kaiso | Wnt signaling pathway | Zbtb33 | Zinc finger and btb domain-containing protein 33 | Zinc-finger | Zinc-finger protein | Znf348
