1h3q

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[[Image:1h3q.gif|left|200px]]
[[Image:1h3q.gif|left|200px]]
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{{Structure
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|PDB= 1h3q |SIZE=350|CAPTION= <scene name='initialview01'>1h3q</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1h3q", creates the "Structure Box" on the page.
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{{STRUCTURE_1h3q| PDB=1h3q | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3q OCA], [http://www.ebi.ac.uk/pdbsum/1h3q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h3q RCSB]</span>
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'''CRYSTAL STURCTURE OF SEDL AT 2.4 ANGSTROMS RESOLUTION'''
'''CRYSTAL STURCTURE OF SEDL AT 2.4 ANGSTROMS RESOLUTION'''
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[[Category: Kim, Y G.]]
[[Category: Kim, Y G.]]
[[Category: Oh, B H.]]
[[Category: Oh, B H.]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: golgi]]
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[[Category: Golgi]]
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[[Category: sedl]]
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[[Category: Sedl]]
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[[Category: sedt]]
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[[Category: Sedt]]
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[[Category: vesicle transport]]
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[[Category: Vesicle transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:23:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:57:03 2008''
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Revision as of 15:23, 2 May 2008

Image:1h3q.gif

Template:STRUCTURE 1h3q

CRYSTAL STURCTURE OF SEDL AT 2.4 ANGSTROMS RESOLUTION


Overview

SEDL is an evolutionarily highly conserved protein in eukaryotic organisms. Deletions or point mutations in the SEDL gene are responsible for the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder. SEDL has been identified as a component of the transport protein particle (TRAPP), critically involved in endoplasmic reticulum-to-Golgi vesicle transport. Herein, we report the 2.4 A resolution structure of SEDL, which reveals an unexpected similarity to the structures of the N-terminal regulatory domain of two SNAREs, Ykt6p and Sec22b, despite no sequence homology to these proteins. The similarity and the presence of unusually many solvent-exposed apolar residues of SEDL suggest that it serves regulatory and/or adaptor functions through multiple protein-protein interactions. Of the four known missense mutations responsible for SEDT, three mutations (S73L, F83S, V130D) map to the protein interior, where the mutations would disrupt the structure, and the fourth (D47Y) on a surface at which the mutation may abrogate functional interactions with a partner protein.

About this Structure

1H3Q is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of SEDL and its implications for a genetic disease spondyloepiphyseal dysplasia tarda., Jang SB, Kim YG, Cho YS, Suh PG, Kim KH, Oh BH, J Biol Chem. 2002 Dec 20;277(51):49863-9. Epub 2002 Oct 1. PMID:12361953 Page seeded by OCA on Fri May 2 18:23:45 2008

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