3nc2
From Proteopedia
(Difference between revisions)
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==X-ray structure of ketohexokinase with a quinazoline== | ==X-ray structure of ketohexokinase with a quinazoline== | ||
- | <StructureSection load='3nc2' size='340' side='right' caption='[[3nc2]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3nc2' size='340' side='right'caption='[[3nc2]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3nc2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3nc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NC2 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUZ:QUINAZOLINE'>QUZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUZ:QUINAZOLINE'>QUZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nbv|3nbv]], [[3nbw|3nbw]], [[3nc9|3nc9]], [[3nca|3nca]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nbv|3nbv]], [[3nbw|3nbw]], [[3nc9|3nc9]], [[3nca|3nca]]</div></td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHK ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
- | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ketohexokinase Ketohexokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.3 2.7.1.3] </span></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nc2 OCA], [https://pdbe.org/3nc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nc2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nc2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN]] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3nc2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3nc2" style="background-color:#fffaf0;"></div> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Ketohexokinase|Ketohexokinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Ketohexokinase]] | [[Category: Ketohexokinase]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Abad, M C]] | [[Category: Abad, M C]] | ||
[[Category: Gibbs, A C]] | [[Category: Gibbs, A C]] |
Revision as of 06:59, 12 May 2022
X-ray structure of ketohexokinase with a quinazoline
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