3ndq
From Proteopedia
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==Structure of Human TFIIS Domain II== | ==Structure of Human TFIIS Domain II== | ||
| - | <StructureSection load='3ndq' size='340' side='right' caption='[[3ndq]], [[Resolution|resolution]] 1.93Å' scene=''> | + | <StructureSection load='3ndq' size='340' side='right'caption='[[3ndq]], [[Resolution|resolution]] 1.93Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ndq]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ndq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NDQ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GTF2S, TCEA1, TFIIS ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GTF2S, TCEA1, TFIIS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ndq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ndq OCA], [https://pdbe.org/3ndq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ndq RCSB], [https://www.ebi.ac.uk/pdbsum/3ndq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ndq ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
==See Also== | ==See Also== | ||
| - | *[[Elongation factor|Elongation factor]] | + | *[[Elongation factor 3D structures|Elongation factor 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Averell, G]] | [[Category: Averell, G]] | ||
[[Category: Hou, J]] | [[Category: Hou, J]] | ||
Revision as of 06:59, 12 May 2022
Structure of Human TFIIS Domain II
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Categories: Human | Large Structures | Averell, G | Hou, J | Hu, X P | Luo, H | Ye, X Y | Helix bundle | Transcription
