3noi
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of Natural Killer Cell Cytotoxicity Receptor NKp30 (NCR3)== | ==Crystal Structure of Natural Killer Cell Cytotoxicity Receptor NKp30 (NCR3)== | ||
| - | <StructureSection load='3noi' size='340' side='right' caption='[[3noi]], [[Resolution|resolution]] 1.84Å' scene=''> | + | <StructureSection load='3noi' size='340' side='right'caption='[[3noi]], [[Resolution|resolution]] 1.84Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3noi]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3noi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NOI FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NKp30, 1C7, LY117, NCR3 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NKp30, 1C7, LY117, NCR3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3noi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3noi OCA], [https://pdbe.org/3noi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3noi RCSB], [https://www.ebi.ac.uk/pdbsum/3noi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3noi ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NCTR3_HUMAN NCTR3_HUMAN]] Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.<ref>PMID:10562324</ref> <ref>PMID:15784725</ref> <ref>PMID:18852879</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 15: | Line 15: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Joyce, M G]] | [[Category: Joyce, M G]] | ||
[[Category: Sun, P D]] | [[Category: Sun, P D]] | ||
Revision as of 07:06, 12 May 2022
Crystal Structure of Natural Killer Cell Cytotoxicity Receptor NKp30 (NCR3)
| |||||||||||
