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1h3z
From Proteopedia
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[[Image:1h3z.jpg|left|200px]] | [[Image:1h3z.jpg|left|200px]] | ||
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'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE''' | '''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE''' | ||
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[[Category: Bycroft, M.]] | [[Category: Bycroft, M.]] | ||
[[Category: Slater, L M.]] | [[Category: Slater, L M.]] | ||
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| - | [[Category: | + | [[Category: Pwwp]] |
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Revision as of 15:24, 2 May 2008
SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE
Overview
The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
About this Structure
1H3Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
Reference
Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472 Page seeded by OCA on Fri May 2 18:24:11 2008
