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3nws
From Proteopedia
(Difference between revisions)
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==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13== | ==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13== | ||
| - | <StructureSection load='3nws' size='340' side='right' caption='[[3nws]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3nws' size='340' side='right'caption='[[3nws]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3nws]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3nws]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWS FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nwt|3nwt]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nwt|3nwt]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nws OCA], [https://pdbe.org/3nws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nws RCSB], [https://www.ebi.ac.uk/pdbsum/3nws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nws ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Atcc 18824]] | [[Category: Atcc 18824]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Harper, S]] | [[Category: Harper, S]] | ||
[[Category: Johnson, F B]] | [[Category: Johnson, F B]] | ||
Revision as of 07:11, 12 May 2022
Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13
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