3o5z
From Proteopedia
(Difference between revisions)
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==Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)== | ==Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)== | ||
| - | <StructureSection load='3o5z' size='340' side='right' caption='[[3o5z]], [[Resolution|resolution]] 2.01Å' scene=''> | + | <StructureSection load='3o5z' size='340' side='right'caption='[[3o5z]], [[Resolution|resolution]] 2.01Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3o5z]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3o5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O5Z FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3R2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3R2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o5z OCA], [https://pdbe.org/3o5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o5z RCSB], [https://www.ebi.ac.uk/pdbsum/3o5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o5z ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN]] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Phosphoinositide 3- | + | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Chen, S]] | [[Category: Chen, S]] | ||
[[Category: Hilgenfeld, R]] | [[Category: Hilgenfeld, R]] | ||
Revision as of 07:16, 12 May 2022
Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)
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