1exz

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Revision as of 14:41, 12 November 2007

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spinqualitylabelsall models 1exz, resolution 2.3Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF STEM CELL FACTOR

Overview

Stem cell factor (SCF) plays important roles in hematopoiesis and the, survival, proliferation, and differentiation of mast cells, melanocytes, and germ cells. SCF mediates its biological effects by binding to and, activating a receptor tyrosine kinase designated c-kit or SCF receptor. In, this report we describe the 2.3-A crystal structure of the functional core, of recombinant human SCF. SCF is a noncovalent homodimer composed of two, slightly wedged protomers. Each SCF protomer exhibits an antiparallel, four-helix bundle fold. Dimerization is mediated by extensive polar and, nonpolar interactions between the two protomers with a large buried, surface area. Finally, we have identified a hydrophobic crevice and a, charged region at the tail of each protomer that functions as a potential, receptor-binding site. On the basis of these observations, a model for SCF, small middle dotc-kit complex formation and dimerization is proposed.

About this Structure

1EXZ is a Single protein structure of sequence from Homo sapiens with SM, CA and TRS as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation., Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP, Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7732-7. PMID:10884405

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